Zellweger spectrum disorders are the spectrum of rare multisystem and autosomal inherited genetic disease which affects most of the organs. Zellweger spectrum disorders are incurred by the defected PEX gene and are covered under peroxisomal biogenesis disorders. According to Orphanet, Zellweger spectrum disorders affects one in every 50,000 individuals in North America and every 500,000 in Japan. These diseases were once categorized as separate entities, however, these different variants are termed as one disease according to their shared biochemical basis.
Zellweger spectrum disorders consist of most severe form Zellweger disorders, intermediate is called neonatal adrenoleukodystrophy and the milder form is called infantile Heimler syndrome (Refsum disease). The symptoms range from hypotonia, Neurological deficits, hearing and vision issues, and liver and kidney abnormalities. Zellweger spectrum disorders can be fatal in the early infancy. Zellweger spectrum disorders are diagnosed with blood and urine tests, etc. The global Zellweger spectrum disorders market is anticipated to grow with the escalating research and progressing clinical understanding of the disease, treatment developments and early diagnosis with the implantation of the newborn screening test. Coronavirus has jolted the growth of the Zellweger spectrum disorders market due to the global and massive shift of attention towards the gigantic influx of coronavirus patients and its vaccine development.
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The progressing research, dedicated organizations and databases, newborn screening tests implementation that helps to diagnose the Zellweger spectrum disorders at an early stage and developing therapies are driving the growth of the global Zellweger spectrum disorders market. However, the global Zellweger spectrum disorders market growth is restrained by the scarce clinical data and limited awareness since Zellweger spectrum disorders is a rare disease, high expense of research, diagnosis and treatment, massive challenges occur in the protocol planning, development and sustainable clinical development of the therapy. Although, the overall growth of the Zellweger spectrum disorders market is expected to revamp with the escalating research and progressing understanding of the disorder, along with the research and treatment advancements, and mandatory newborn screening tests in nations such as the U.S.
The global Zellweger spectrum disorders market is segmented into therapy, diagnosis, end-user and regions.
By therapy, the global Zellweger spectrum disorders market is further segmented into:
- Audiologists (treat hearing problems)
- Ophthalmologists (treat vision problems)
- Orthopedists (treat skeletal abnormalities)
By diagnosis, the global Zellweger spectrum disorders market is further segmented into:
- Blood and Urine test
- Genetic tests
By end-user, the global Zellweger spectrum disorders market is further segmented into:
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The global Zellweger spectrum disorders market is anticipated to grow with the escalating research and therapy advancements. By therapy, the segment is divided into pediatricians, neurologists, Surgeons, Audiologists for hearing issues, ophthalmologists for vision issues and Orthopedists for skeletal abnormalities. By diagnosis, the Zellweger spectrum disorders market is divided into blood and urine test, ultrasound and genetic test. Initial diagnosis includes blood and urine test to check the elevated level of very-long-chain fatty acids (VLCFA). By end-user, hospitals dominates the segment with the advanced diagnosis and treatment of the Zellweger spectrum disorders, with close collaboration with research institutes.
North America is anticipated to dominate the global Zellweger spectrum disorders market with its advanced research and healthcare infrastructure, mandatory newborn screening test and sophisticated diagnostics. Europe is anticipated to hold the second-largest Zellweger spectrum disorders market with the initiatives of newborn screening tests, dedicated research programs and collaborations. Asia-Pacific Zellweger spectrum disorders market is expected to grow in future with the research progress and new findings and advancing diagnostics. Latin America Zellweger spectrum disorders market is expected to grow with a slow pace since its research is at its infancy, challenges in research and diagnostics. The Middle East& Africa Zellweger spectrum disorders market is expected to remain stagnant due to the underdeveloped research and healthcare infrastructure and lack of awareness.
The key players of Zellweger spectrum disorders market include PerkinElmers Inc., Trivitron Healthcare, Chromsystems Instruments & Chemicals GmbH., CENTOGENE N.V., LifeCell International Pvt. Ltd., Bio-Rad Laboratories, Inc., Beckman Coulter, Inc., F. Hoffmann-La Roche Ltd, Seimens and others.
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